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human breast cancer xenium dataset  (10X Genomics)

 
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    10X Genomics human breast cancer xenium dataset
    Neighborhood analysis reveals immune cell distribution differences around tumor and DCIS regions. ( a ) Spatial plot of <t>Xenium</t> <t>breast</t> <t>cancer</t> tissue colored by cell type annotations. Neighbor ring regions surrounding tumor and DCIS are shown separately for clarity. Blue indicates tumor-associated rings; yellow indicates DCIS-associated rings. ( b ) Cells located within tumor and DCIS neighbor rings. ( c ) Overall cell type proportions in tumor and DCIS neighbor rings. Cells from all rings are aggregated for each condition to compute relative frequencies (labels shown for proportions \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} $\ge$\end{document} 2%). ( d ) Row-scaled spatial interaction matrices showing the frequency of neighboring cell types around each focal cell type within tumor and DCIS neighborhoods. ( e ) Spatial distribution of major immune cell types, including T cells, macrophages, plasma cells, and B cells. Blue and yellow polygons indicate boundaries of tumor and DCIS, respectively. Notably, T, B, and plasma cells appear more enriched near DCIS than tumor regions. ( f ) Bar plot comparing T cell proportions between tumor and DCIS neighbor rings. Blue bars represent tumor-associated neighborhoods and yellow bars represent DCIS. The T cell proportion is significantly higher near DCIS (Student’s t -test, P = .012).
    Human Breast Cancer Xenium Dataset, supplied by 10X Genomics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+breast+cancer+xenium+dataset/pmc13069690-271-0-5?v=10X+Genomics
    Average 86 stars, based on 1 article reviews
    human breast cancer xenium dataset - by Bioz Stars, 2026-08
    86/100 stars

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    1) Product Images from "SpNeigh: spatial neighborhood and differential expression analysis for high-resolution spatial transcriptomics"

    Article Title: SpNeigh: spatial neighborhood and differential expression analysis for high-resolution spatial transcriptomics

    Journal: NAR Genomics and Bioinformatics

    doi: 10.1093/nargab/lqag039

    Neighborhood analysis reveals immune cell distribution differences around tumor and DCIS regions. ( a ) Spatial plot of Xenium breast cancer tissue colored by cell type annotations. Neighbor ring regions surrounding tumor and DCIS are shown separately for clarity. Blue indicates tumor-associated rings; yellow indicates DCIS-associated rings. ( b ) Cells located within tumor and DCIS neighbor rings. ( c ) Overall cell type proportions in tumor and DCIS neighbor rings. Cells from all rings are aggregated for each condition to compute relative frequencies (labels shown for proportions \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} $\ge$\end{document} 2%). ( d ) Row-scaled spatial interaction matrices showing the frequency of neighboring cell types around each focal cell type within tumor and DCIS neighborhoods. ( e ) Spatial distribution of major immune cell types, including T cells, macrophages, plasma cells, and B cells. Blue and yellow polygons indicate boundaries of tumor and DCIS, respectively. Notably, T, B, and plasma cells appear more enriched near DCIS than tumor regions. ( f ) Bar plot comparing T cell proportions between tumor and DCIS neighbor rings. Blue bars represent tumor-associated neighborhoods and yellow bars represent DCIS. The T cell proportion is significantly higher near DCIS (Student’s t -test, P = .012).
    Figure Legend Snippet: Neighborhood analysis reveals immune cell distribution differences around tumor and DCIS regions. ( a ) Spatial plot of Xenium breast cancer tissue colored by cell type annotations. Neighbor ring regions surrounding tumor and DCIS are shown separately for clarity. Blue indicates tumor-associated rings; yellow indicates DCIS-associated rings. ( b ) Cells located within tumor and DCIS neighbor rings. ( c ) Overall cell type proportions in tumor and DCIS neighbor rings. Cells from all rings are aggregated for each condition to compute relative frequencies (labels shown for proportions \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} $\ge$\end{document} 2%). ( d ) Row-scaled spatial interaction matrices showing the frequency of neighboring cell types around each focal cell type within tumor and DCIS neighborhoods. ( e ) Spatial distribution of major immune cell types, including T cells, macrophages, plasma cells, and B cells. Blue and yellow polygons indicate boundaries of tumor and DCIS, respectively. Notably, T, B, and plasma cells appear more enriched near DCIS than tumor regions. ( f ) Bar plot comparing T cell proportions between tumor and DCIS neighbor rings. Blue bars represent tumor-associated neighborhoods and yellow bars represent DCIS. The T cell proportion is significantly higher near DCIS (Student’s t -test, P = .012).

    Techniques Used: Clinical Proteomics



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    human breast cancer xenium dataset  (10X Genomics)
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    Neighborhood analysis reveals immune cell distribution differences around tumor and DCIS regions. ( a ) Spatial plot of <t>Xenium</t> <t>breast</t> <t>cancer</t> tissue colored by cell type annotations. Neighbor ring regions surrounding tumor and DCIS are shown separately for clarity. Blue indicates tumor-associated rings; yellow indicates DCIS-associated rings. ( b ) Cells located within tumor and DCIS neighbor rings. ( c ) Overall cell type proportions in tumor and DCIS neighbor rings. Cells from all rings are aggregated for each condition to compute relative frequencies (labels shown for proportions \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} $\ge$\end{document} 2%). ( d ) Row-scaled spatial interaction matrices showing the frequency of neighboring cell types around each focal cell type within tumor and DCIS neighborhoods. ( e ) Spatial distribution of major immune cell types, including T cells, macrophages, plasma cells, and B cells. Blue and yellow polygons indicate boundaries of tumor and DCIS, respectively. Notably, T, B, and plasma cells appear more enriched near DCIS than tumor regions. ( f ) Bar plot comparing T cell proportions between tumor and DCIS neighbor rings. Blue bars represent tumor-associated neighborhoods and yellow bars represent DCIS. The T cell proportion is significantly higher near DCIS (Student’s t -test, P = .012).
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    Neighborhood analysis reveals immune cell distribution differences around tumor and DCIS regions. ( a ) Spatial plot of <t>Xenium</t> <t>breast</t> <t>cancer</t> tissue colored by cell type annotations. Neighbor ring regions surrounding tumor and DCIS are shown separately for clarity. Blue indicates tumor-associated rings; yellow indicates DCIS-associated rings. ( b ) Cells located within tumor and DCIS neighbor rings. ( c ) Overall cell type proportions in tumor and DCIS neighbor rings. Cells from all rings are aggregated for each condition to compute relative frequencies (labels shown for proportions \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} $\ge$\end{document} 2%). ( d ) Row-scaled spatial interaction matrices showing the frequency of neighboring cell types around each focal cell type within tumor and DCIS neighborhoods. ( e ) Spatial distribution of major immune cell types, including T cells, macrophages, plasma cells, and B cells. Blue and yellow polygons indicate boundaries of tumor and DCIS, respectively. Notably, T, B, and plasma cells appear more enriched near DCIS than tumor regions. ( f ) Bar plot comparing T cell proportions between tumor and DCIS neighbor rings. Blue bars represent tumor-associated neighborhoods and yellow bars represent DCIS. The T cell proportion is significantly higher near DCIS (Student’s t -test, P = .012).
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    Image Search Results


    Neighborhood analysis reveals immune cell distribution differences around tumor and DCIS regions. ( a ) Spatial plot of Xenium breast cancer tissue colored by cell type annotations. Neighbor ring regions surrounding tumor and DCIS are shown separately for clarity. Blue indicates tumor-associated rings; yellow indicates DCIS-associated rings. ( b ) Cells located within tumor and DCIS neighbor rings. ( c ) Overall cell type proportions in tumor and DCIS neighbor rings. Cells from all rings are aggregated for each condition to compute relative frequencies (labels shown for proportions \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} $\ge$\end{document} 2%). ( d ) Row-scaled spatial interaction matrices showing the frequency of neighboring cell types around each focal cell type within tumor and DCIS neighborhoods. ( e ) Spatial distribution of major immune cell types, including T cells, macrophages, plasma cells, and B cells. Blue and yellow polygons indicate boundaries of tumor and DCIS, respectively. Notably, T, B, and plasma cells appear more enriched near DCIS than tumor regions. ( f ) Bar plot comparing T cell proportions between tumor and DCIS neighbor rings. Blue bars represent tumor-associated neighborhoods and yellow bars represent DCIS. The T cell proportion is significantly higher near DCIS (Student’s t -test, P = .012).

    Journal: NAR Genomics and Bioinformatics

    Article Title: SpNeigh: spatial neighborhood and differential expression analysis for high-resolution spatial transcriptomics

    doi: 10.1093/nargab/lqag039

    Figure Lengend Snippet: Neighborhood analysis reveals immune cell distribution differences around tumor and DCIS regions. ( a ) Spatial plot of Xenium breast cancer tissue colored by cell type annotations. Neighbor ring regions surrounding tumor and DCIS are shown separately for clarity. Blue indicates tumor-associated rings; yellow indicates DCIS-associated rings. ( b ) Cells located within tumor and DCIS neighbor rings. ( c ) Overall cell type proportions in tumor and DCIS neighbor rings. Cells from all rings are aggregated for each condition to compute relative frequencies (labels shown for proportions \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} $\ge$\end{document} 2%). ( d ) Row-scaled spatial interaction matrices showing the frequency of neighboring cell types around each focal cell type within tumor and DCIS neighborhoods. ( e ) Spatial distribution of major immune cell types, including T cells, macrophages, plasma cells, and B cells. Blue and yellow polygons indicate boundaries of tumor and DCIS, respectively. Notably, T, B, and plasma cells appear more enriched near DCIS than tumor regions. ( f ) Bar plot comparing T cell proportions between tumor and DCIS neighbor rings. Blue bars represent tumor-associated neighborhoods and yellow bars represent DCIS. The T cell proportion is significantly higher near DCIS (Student’s t -test, P = .012).

    Article Snippet: Human breast cancer Xenium dataset: https://www.10xgenomics.com/products/xenium-in-situ/preview-dataset-human-breast [ ].

    Techniques: Clinical Proteomics